Unruptured anterior communicating artery aneurysm with co-existing blister aneurysms: Case report and review of literature

Blister aneurysms are a separate class of vascular malformations with a unique etiopathogenesis and clinical profile, elusive to radiological imaging and complex to manage. Unless identified and managed appropriately they often lead increased morbidity intra and post operatively. They are commonly reported in internal carotid artery. We are reporting a rare case of intraoperatively diagnosed blister aneurysm of the anterior cerebral artery, the management options and the importance of constant vigilance in cases where the aneurysm appears unruptured intraoperatively

PRIMA General Observer Science Book

PRIMA (The PRobe for-Infrared Mission for Astrophysics) is a concept for a far-infrared (IR) observatory. PRIMA features a cryogenically cooled 1.8 m diameter telescope and is designed to carry two science instruments enabling ultra-high sensitivity imaging and spectroscopic studies in the 24 to 235 microns wavelength range. The resulting observatory is a powerful survey and discovery machine, with mapping speeds better by 2 - 4 orders of magnitude with respect to its far-IR predecessors. The bulk of the observing time on PRIMA should be made available to the community through a General Observer (GO) program offering 75% of the mission time over 5 years. In March 2023, the international astronomy community was encouraged to prepare authored contributions articulating scientific cases that are enabled by the telescope massive sensitivity advance and broad spectral coverage, and that could be performed within the context of GO program. This document, the PRIMA General Observer Science Book, is the edited collection of the 76 received contributions.Comment: A. Moullet, T. Kataria, D. Lis, S. Unwin, Y. Hasegawa, E. Mills, C. Battersby, A. Roc, M. Meixner are the editors of the PRIMA General Observer Science Book. The book compiles 76 authored contributions. 399 page

Radial velocity eclipse mapping of exoplanets

Planetary rotation rates and obliquities provide information regarding the history of planet formation, but have not yet been measured for evolved extrasolar planets. Here we investigate the theoretical and observational perspective of the Rossiter-McLauglin effect during secondary eclipse (RMse) ingress and egress for transiting exoplanets. Near secondary eclipse, when the planet passes behind the parent star, the star sequentially obscures light from the approaching and receding parts of the rotating planetary surface. The temporal block of light emerging from the approaching (blue-shifted) or receding (red-shifted) parts of the planet causes a temporal distortion in the planet's spectral line profiles resulting in an anomaly in the planet's radial velocity curve. We demonstrate that the shape and the ratio of the ingress-to-egress radial velocity amplitudes depends on the planetary rotational rate, axial tilt and impact factor (i.e. sky-projected planet spin-orbital alignment). In addition, line asymmetries originating from different layers in the atmosphere of the planet could provide information regarding zonal atmospheric winds and constraints on the hot spot shape for giant irradiated exoplanets. The effect is expected to be most-pronounced at near-infrared wavelengths, where the planet-to-star contrasts are large. We create synthetic near-infrared, high-dispersion spectroscopic data and demonstrate how the sky-projected spin axis orientation and equatorial velocity of the planet can be estimated. We conclude that the RMse effect could be a powerful method to measure exoplanet spins.Comment: 7 pages, 3 figures, 1 table, accepted for publication in ApJ on 2015 June 1

Method comparison studies of telomere length measurement using qPCR approaches:A critical appraisal of the literature

Use of telomere length (TL) as a biomarker for various environmental exposures and diseases has increased in recent years. Various methods have been developed to measure telomere length. Polymerase chain reaction (PCR)-based methods remain wide-spread for population-based studies due to the high-throughput capability. While several studies have evaluated the repeatability and reproducibility of different TL measurement methods, the results have been variable. We conducted a literature review of TL measurement cross-method comparison studies that included a PCR-based method published between January 1, 2002 and May 25, 2020. A total of 25 articles were found that matched the inclusion criteria. Papers were reviewed for quality of methodologic reporting of sample and DNA quality, PCR assay characteristics, sample blinding, and analytic approaches to determine final TL. Overall, methodologic reporting was low as assessed by two different reporting guidelines for qPCR-based TL measurement. There was a wide range in the reported correlation between methods (as assessed by Pearson's r) and few studies utilized the recommended intra-class correlation coefficient (ICC) for assessment of assay repeatability and methodologic comparisons. The sample size for nearly all studies was less than 100, raising concerns about statistical power. Overall, this review found that the current literature on the relation between TL measurement methods is lacking in validity and scientific rigor. In light of these findings, we present reporting guidelines for PCR-based TL measurement methods and results of analyses of the effect of assay repeatability (ICC) on statistical power of cross-sectional and longitudinal studies. Additional cross-laboratory studies with rigorous methodologic and statistical reporting, adequate sample size, and blinding are essential to accurately determine assay repeatability and replicability as well as the relation between TL measurement methods

Superconducting ground state study of valence skip compound AgSnSe2_2

The valence-skipped superconductors are natural candidates for unconventional superconductivity, as they can exhibit a negative effective, attractive interaction for electron-pairing. This work reports comprehensive XRD, magnetization, specific heat and muon spin rotation and relaxation measurements ($\mu$SR) on a valence-skipped compound: AgSnSe$_2$. The temperature dependence of the electronic specific heat ($C_{el}(T)$) and of the upper critical field ($H_{c2}(T)$) provide evidence of two-gap superconductivity, which is also confirmed by our transverse-field $\mu$SR measurements. Our zero-field $\mu$SR measurements suggest preserved time-reversal symmetry in the superconducting ground state of AgSnSe$_2$.Comment: 8 pages, 6 figure

EDGE: The direct link between mass growth history and the extended stellar haloes of the faintest dwarf galaxies

Ultra-faint dwarf galaxies (UFDs) are commonly found in close proximity to the Milky Way and other massive spiral galaxies. As such, their projected stellar ellipticity and extended light distributions are often thought to owe to tidal forces. In this paper, we study the projected stellar ellipticities and faint stellar outskirts of tidally isolated ultra-faints drawn from the 'Engineering Dwarfs at Galaxy Formation's Edge' (EDGE) cosmological simulation suite. Despite their tidal isolation, our simulated dwarfs exhibit a wide range of projected ellipticities ($0.03 < \varepsilon < 0.85$), with many possessing anisotropic extended stellar haloes that mimic tidal tails, but owe instead to late-time accretion of lower mass companions. Furthermore, we find a strong causal relationship between ellipticity and formation time of an UFD, which is robust to a wide variation in the feedback model. We show that the distribution of projected ellipticities in our suite of simulated EDGE dwarfs matches well with that of 21 Local Group dwarf galaxies. Given the ellipticity in EDGE arises from an ex-situ accretion origin, the agreement in shape indicates the ellipticities of some observed dwarfs may also originate from a similar non-tidal scenario. The orbital parameters of these observed dwarfs further support that they are not currently tidally disrupting. If the baryonic content in these galaxies is still tidally intact, then the same may be true for their dark matter content, making these galaxies in our Local Group pristine laboratories for testing dark matter and galaxy formation models.Comment: 10 pages, 4 figures; submitted to MNRA

In-flight calibration of the Cluster PEACE sensors

The Plasma Electron and Current Experiment (PEACE) instruments operate on all four of the Cluster spacecraft and measure the 3-D velocity distribution of electrons in the energy range from 0.59 eV to 26.4 keV during each spacecraft spin. Pitch angle distributions and moments of the velocity distribution are also produced. As the mission has progressed, the efficiency of the detectors has declined. Several factors may play a role in this decline such as exposure to radiation, high electron fluxes and spacecraft thruster firings. To account for these variations, continuous in-flight calibration work is essential. The purpose of this paper is to describe the PEACE calibration parameters, focussing in particular on those that vary over time, and to describe the methods which are used to determine their evolution

Spitzer phase curve observations and circulation models of the inflated ultra-hot Jupiter WASP-76b

The large radii of many hot Jupiters can only be matched by models that have hot interior adiabats, and recent theoretical work has shown that the interior evolution of hot Jupiters has a significant impact on their atmospheric structure. Due to its inflated radius, low gravity, and ultra-hot equilibrium temperature, WASP-76b is an ideal case study for the impact of internal evolution on observable properties. Hot interiors should most strongly affect the non-irradiated side of the planet, and thus full phase curve observations are critical to ascertain the effect of the interior on the atmospheres of hot Jupiters. In this work, we present the first Spitzer phase curve observations of WASP-76b. We find that WASP-76b has an ultra-hot day side and relatively cold nightside with brightness temperatures of $2471 \pm 27~\mathrm{K}$/$1518 \pm 61~\mathrm{K}$ at 3.6~\micron and $2699 \pm 32~\mathrm{K}$/$1259 \pm 44~\mathrm{K}$ at 4.5~\micron, respectively. These results provide evidence for a dayside thermal inversion. Both channels exhibit small phase offsets of $0.68 \pm 0.48^{\circ}$ at 3.6~\micron and $0.67 \pm 0.2^{\circ}$ at $4.5~\mu\mathrm{m}$. We compare our observations to a suite of general circulation models that consider two end-members of interior temperature along with a broad range of frictional drag strengths. Strong frictional drag is necessary to match the small phase offsets and cold nightside temperatures observed. From our suite of cloud-free GCMs, we find that only cases with a cold interior can reproduce the cold nightsides and large phase curve amplitude at 4.5~\micron, hinting that the hot interior adiabat of WASP-76b does not significantly impact its atmospheric dynamics or that clouds blanket its nightside.Comment: 24 pages, 10 Figures, 5 Tables. Accepted to AJ. Co-First Author

Successful treatment of recalcitrant cutaneous sarcoidosis with fumaric acid esters

BACKGROUND: Sarcoidosis is a multisystem disease of unknown origin characterized by the formation of noncaseating granulomas, in particular in the lungs, lymph nodes, eyes, and skin. Systemic treatment for cutaneous sarcoidosis can be used for large disfiguring lesions, generalized involvement, or recalcitrant lesions that did not respond to topical therapy. CASE PRESENTATIONS: We report three patients with recalcitrant cutaneous sarcoidosis who were treated with oral fumaric acid esters (FAE). Three female patients presented with cutaneous sarcoidosis that have proved to be refractory to various therapies, including corticosteroids and chloroquine. We treated the patients with FAE in tablet form using two formulations differing in strength (Fumaderm(® )initial, Fumaderm(®)). Dosage of FAE was performed according to the standard therapy regimen for psoriasis patients. After treatment with FAE (4–12 months), a complete clearance of skin lesions was achieved in the three patients. The side effects observed in this trial correspond to the well-known spectrum of adverse effects of FAE (flush, minor gastrointestinal complaints, lymphopenia). CONCLUSIONS: On the basis of our findings FAE therapy seems to be a safe and effective regimen for patients with recalcitrant cutaneous sarcoidosis. Nevertheless further investigations are necessary to confirm our preliminary results